DETERMINATION OF CEFIXIME AND ITS METABOLITES BY HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS

被引：42

作者：

HONDA, S

TAGA, A

KAKEHI, K

KODA, S

OKAMOTO, Y

机构：

[1] KINKI UNIV,FAC PHARMACEUT SCI,HIGASHIOSAKA,OSAKA 577,JAPAN

[2] KINKI UNIV,INST TECHNOL,HIGASHIOSAKA,OSAKA 577,JAPAN

[3] FUJISAWA PHARMACEUT CO LTD,RES LABS,YODOGAWA KU,OSAKA 532,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 590卷 / 02期

关键词：

D O I：

10.1016/0021-9673(92)85400-N

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Cefixime (CX), an oral cephalosporin antibiotic, and its metabolites in human digestive organs were separated by various modes of high-performance capillary electrophoresis. The zone electrophoresis mode in phosphate buffer (pH 6.8) containing 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulphonate gave the best separation, permitting the complete resolution of CX and all of five metabolites. On the other hand, the plain zone electrophoresis mode in phosphate buffer (pH 6.8) offered a simple procedure for the direct determination of urinary CX concentration using intact urine samples.

引用

页码：364 / 368

页数：5

共 5 条

[1] RAPID SEPARATION AND PURIFICATION OF OLIGONUCLEOTIDES BY HIGH-PERFORMANCE CAPILLARY GEL-ELECTROPHORESIS [J].