SYNTHETIC STUDIES ON ENZYME-INHIBITORS .2. SYNTHESIS OF (-)-ALLOSAMIZOLINE, THE PSEUDOAMINOSUGAR MOIETY OF ALLOSAMIDIN, A CHITINASE INHIBITOR

被引：20

作者：

KITAHARA, T ^{[1
]}

SUZUKI, N ^{[1
]}

KOSEKI, K ^{[1
]}

MORI, K ^{[1
]}

机构：

[1] JAPAN TOBACCO INC, LIFE SCI RES LAB, MIDORI KU, YOKOHAMA 227, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1993年 / 57卷 / 11期

关键词：

D O I：

10.1271/bbb.57.1906

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantioselective synthesis of (-)-allosamizoline (2a), the aminocyclitol moiety of allosamidin (1a), was achieved by starting from D-glucosamine (3). Intramolecular nitrile oxide cycloaddition was adopted as the kev step to construct a functional cyclopentane ring system with proper stereochemistry.

引用

页码：1906 / 1909

页数：4

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