ZONAL DISTRIBUTION OF CHONDROITIN-4-SULFATE DERMATAN SULFATE AND CHONDROITIN-6-SULFATE IN NORMAL AND DISEASED HUMAN SYNOVIUM

被引：27

作者：

WORRALL, JG ^{[1
]}

WILKINSON, LS ^{[1
]}

BAYLISS, MT ^{[1
]}

EDWARDS, JCW ^{[1
]}

机构：

[1] KENNEDY INST,LONDON W6 7DW,ENGLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1994年 / 53卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1136/ard.53.1.35

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives-Chondroitin sulphate is the major sulphated glycosaminoglycan present in the extracellular matrix of soft connective tissues and the aim of this study was to investigate the distribution of chondroitin sulphate species in normal and diseased synovium. Methods-Distribution of chondroitin-4-sulphate/dermatan sulphate (Ch4S/DS) and chondroitin-6-sulphate in normal (n = 6), osteoarthritic (n = 4) and rheumatoid (n = 10) synovium was determined using an immunoperoxidase technique and specific monoclonal antibodies to chondroitinase ABC-digested preparations. Results-Ch4S/DS was expressed throughout the interstitium of all tissues and was also present on blood vessels in rheumatoid samples only. Ch6S was expressed in the lining layer of normal synovium but was absent from this site in osteoarthritic and rheumatoid tissues. Ch6S was also present on all blood vessels in all tissues. Conclusions-The distinct zonal distributions of Ch4S/DS and Ch6S and their alteration in disease suggest these molecules have different and specific functions in normal and diseased synovium.

引用

页码：35 / 38

页数：4

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