HUMAN PARAINFLUENZA VIRUS INDUCES A TYPE-SPECIFIC PROTECTIVE IMMUNE-RESPONSE

被引：14

作者：

RAY, R ^{[1
]}

MATSUOKA, Y ^{[1
]}

BURNETT, TL ^{[1
]}

GLAZE, BJ ^{[1
]}

COMPANS, RW ^{[1
]}

机构：

[1] UNIV ALABAMA,DEPT MICROBIOL,BIRMINGHAM,AL 35294

来源：

JOURNAL OF INFECTIOUS DISEASES | 1990年 / 162卷 / 03期

关键词：

D O I：

10.1093/infdis/162.3.746

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Induction of type-specific and cross-protective immune responses against human parainfluenza viruses have been investigated. The envelope glycoproteins HN (76 kDa) and F0 (62 kDa) from parainfluenza type 2 virus were selectively solubilized with octylglucoside. Detergent-soluble envelope glycoproteins were used as vaccine antigens for intranasal immunization of hamsters. The immunized animals showed complete protection from challenge infection with prototype live virus but failed to demonstrate a significant level of protection against either human parainfluenza type 1 or type 3 virus. The sera and bronchial lavages of immunized animals also showed type specific neutralizing antibodies. A similar type-specific protective immune response was also noted after primary infection with live virus. The results indicate that a multivalent parainfluenza virus vaccine is probably required for protection against natural infection. © 1990, by The University of Chicago.

引用

页码：746 / 749

页数：4

共 15 条

[1]

CHANOCK RM, 1985, VIROLOGY, P1241

[2]

COELINGH KLV, 1988, J INFECT DIS, V157, P655, DOI DOI 10.1093/INFDIS/157.4.655

[3] INVIVO ANTIGENIC STUDIES OF PARAINFLUENZA VIRUSES [J].