A NOVEL METALLOPROTEINASE ORIGINALLY ISOLATED FROM BRAIN MYELIN MEMBRANES IS PRESENT IN MANY TISSUES

被引:16
作者
CHANTRY, A [1 ]
GLYNN, P [1 ]
机构
[1] INST NEUROL,DEPT NEUROCHEM,LONDON WC1N 1PJ,ENGLAND
关键词
D O I
10.1042/bj2680245
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A monoclonal antibody, CG4, was raised to a novel 60 kDa metalloproteinase purified from a bovine brain myelin glycoprotein fraction. Glycoproteins extracted from both myelin and nine different bovine tissues showed the 60 kDa CG4-immunoreactive band by immunoblotting in amounts that broadly paralleled enzymic activity of this metalloproteinase and varied relatively little among the tissues.
引用
收藏
页码:245 / 248
页数:4
相关论文
共 16 条
  • [1] PURIFICATION AND CHARACTERIZATION OF A METALLO-ENDOPROTEINASE FROM MOUSE KIDNEY
    BEYNON, RJ
    SHANNON, JD
    BOND, JS
    [J]. BIOCHEMICAL JOURNAL, 1981, 199 (03) : 591 - 598
  • [2] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
  • [3] METALLOENDOPROTEASE CLEAVAGE OF 18.2-KILODALTON AND 14.1-KILODALTON BASIC-PROTEINS DISSOCIATING FROM RODENT MYELIN MEMBRANES GENERATES 10.0-KILODALTON AND 5.9-KILODALTON C-TERMINAL FRAGMENTS
    CHANTRY, A
    EARL, C
    GROOME, N
    GLYNN, P
    [J]. JOURNAL OF NEUROCHEMISTRY, 1988, 50 (03) : 688 - 694
  • [4] CHANTRY A, 1989, J BIOL CHEM, V264, P21603
  • [5] Dunkley P. R., 1974, RESEARCH METHODS NEU, V2, P219
  • [6] Galfre G, 1981, Methods Enzymol, V73, P3
  • [7] AN IMMUNORADIOMETRIC ASSAY FOR ENDOPEPTIDASE-24.11 SHOWS IT TO BE A WIDELY DISTRIBUTED ENZYME IN PIG-TISSUES
    GEE, NS
    BOWES, MA
    BUCK, P
    KENNY, AJ
    [J]. BIOCHEMICAL JOURNAL, 1985, 228 (01) : 119 - 126
  • [8] BASIC-PROTEIN DISSOCIATING FROM MYELIN MEMBRANES AT PHYSIOLOGICAL IONIC-STRENGTH AND PH IS CLEAVED INTO 3 MAJOR FRAGMENTS
    GLYNN, P
    CHANTRY, A
    GROOME, N
    CUZNER, ML
    [J]. JOURNAL OF NEUROCHEMISTRY, 1987, 48 (03) : 752 - 759
  • [9] A NEW EPITOPE ON HUMAN MYELIN BASIC-PROTEIN ARISING FROM CLEAVAGE BY A METALLOENDOPROTEASE ASSOCIATED WITH BRAIN MYELIN MEMBRANES
    GROOME, N
    CHANTRY, A
    EARL, C
    NEWCOMBE, J
    KEEN, J
    FINDLAY, J
    GLYNN, P
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 1988, 19 (1-2) : 77 - 88
  • [10] ENDOPEPTIDASE-24.11 - A CELL-SURFACE ENZYME FOR METABOLIZING REGULATORY PEPTIDES
    KENNY, AJ
    BOWES, MA
    GEE, NS
    MATSAS, R
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1985, 13 (02) : 293 - 295