EFFECT OF IBOTENIC ACID LESIONS OF THE MEDIAL PREFRONTAL CORTEX ON AMPHETAMINE-INDUCED LOCOMOTION AND REGIONAL BRAIN CATECHOLAMINE CONCENTRATIONS IN THE RAT

被引：118

作者：

JASKIW, GE ^{[1
]}

KAROUM, F ^{[1
]}

FREED, WJ ^{[1
]}

PHILLIPS, I ^{[1
]}

KLEINMAN, JE ^{[1
]}

WEINBERGER, DR ^{[1
]}

机构：

[1] ST ELIZABETH HOSP, NIMH, INTRAMURAL RES PROGRAM, NEUROPSYCHIAT BRANCH, WASHINGTON, DC 20032 USA

来源：

BRAIN RESEARCH | 1990年 / 534卷 / 1-2期

关键词：

Amphetamine; Corpus striatum; Dopamine; Ibotenic acid; Locomotor response; Prefrontal cortex;

D O I：

10.1016/0006-8993(90)90138-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine the influence of intrinsic medial prefrontal cortex (MPFC) neurons on regional brain catecholamine turnover, dopamine (DA) and its metabolites were assayed in several brain areas 14 and 28 days after bilateral ibotenic acid (IA) lesions of the MPFC in the rat. The locomotor response to d-amphetamine was also assessed. On the 14th postoperative day levels of DA, homovanillic acid concentrations and 3,4-dihydroxyphenylacetic acid were elevated in the anterior striatum of IA-lesioned animals. Spontaneous and amphetamine-induced locomotion were also increased. These changes disappeared by the 28th postoperative day. It is concluded that destruction of the efferents of the MPFC induces transient increases in DA turnover within the medial striatum and transiently increases spontaneous and amphetamine-induced locomotion. © 1990.

引用

页码：263 / 272

页数：10

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