DEMONSTRATION OF INHIBITION OF CYCLIC-AMP ACCUMULATION IN BRAIN BY VERY LOW CONCENTRATIONS OF LITHIUM IN THE PRESENCE OF ALPHA-ADRENOCEPTOR BLOCKADE

被引：17

作者：

MARMOL, F

CARBONELL, L

CUFFI, ML

FORN, J

机构：

[1] Unitat de Farmacologia, Terapéutica i Farmacologia Clínica, Facultat de Medicina, Barcelona

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 226卷 / 01期

关键词：

LITHIUM CHLORIDE; CAMP; NOREPINEPHRINE; ISOPRENALINE; PHENOXYBENZAMINE; PROPRANOLOL;

D O I：

10.1016/0922-4106(92)90087-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present paper, we have studied the effect of lithium on cAMP levels induced by isoprenaline and norepinephrine in thc presence of alpha- or beta-adrenoceptor antagonists. Our results show that low lithium concentrations, starting at 0.3 X 10(-3) M, have a significant inhibitory effect on cAMP content induced by isoprenaline in brain tissue pretreated with thc alpha-adrenoceptor blocker phenoxybenzamine. On the other hand, the inhibitory effect of lithium on cAMP levels induced by norepinephrine when beta-adrenoceptors are blocked with propranolol, is observed at concentrations starting at 2.5 X 10(-3) M. These results show that in the presence of alpha-blockade, low lithium concentrations which are within the therapeutic plasma range for treatment of manic patients, are able to act on an adenylate cyclase-cAMP system coupled to beta-adrenoceptors.

引用

页码：93 / 96

页数：4

共 16 条

[1] MAGNESIUM REVERSAL OF LITHIUM INHIBITION OF BETA-ADRENERGIC AND MUSCARINIC RECEPTOR COUPLING TO G-PROTEINS [J].