QUERCETIN-INDUCED LIPID-PEROXIDATION AND DNA DAMAGE IN ISOLATED RAT-LIVER NUCLEI

被引：36

作者：

SAHU, SC

WASHINGTON, MC

机构：

[1] Molecular Toxicology Laboratory, Division of Toxicological Studies, Food and Drug Administration, Washington

来源：

CANCER LETTERS | 1991年 / 58卷 / 1-2期

关键词：

QUERCETIN; FLAVONOIDS; DNA DAMAGE; LIPID PEROXIDATION; OXYGEN RADICAL;

D O I：

10.1016/0304-3835(91)90026-E

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The extent of lipid peroxidation and DNA damage induced by quercetin were studied under aerobic conditions in isolated rat-liver nuclei. The effects of iron and copper ions on these two toxic oxidative processes were also investigated. Quercetin induced significant (P < 0.05) concentration-dependent nuclear lipid peroxidation concurrent with DNA degradation; these effects were enhanced by iron and copper ions. The results suggest that the reactive oxygen species generated by quercetin autoxidation, catalyzed by iron and copper ions, are responsible for the concurrent lipid peroxidation and DNA damage in isolated rat-liver nuclei.

引用

页码：75 / 79

页数：5

共 35 条

[1] A SUPEROXIDE ANION INDUCED DNA STRAND-BREAK METABOLIC PATHWAY IN HUMAN-LEUKOCYTES - EFFECTS OF VANADATE [J].

BIRNBOIM, HC .

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1988, 66 (05) :374-381

[2] DNA STRAND BREAKS IN HUMAN-LEUKOCYTES INDUCED BY SUPEROXIDE ANION, HYDROGEN-PEROXIDE AND TUMOR PROMOTERS ARE REPAIRED SLOWLY COMPARED TO BREAKS INDUCED BY IONIZING-RADIATION [J].

BIRNBOIM, HC .

CARCINOGENESIS, 1986, 7 (09) :1511-1517

[3]

BIRNBOIM HC, 1981, CANCER RES, V41, P1889

[4] A REVIEW OF THE GENETIC-EFFECTS OF NATURALLY-OCCURRING FLAVONOIDS, ANTHRAQUINONES AND RELATED-COMPOUNDS [J].

BROWN, JP .

MUTATION RESEARCH, 1980, 75 (03) :243-277

[5]

COX R, 1973, CANCER RES, V33, P2114

[6] RECENT FINDINGS ON THE GENETIC TOXICOLOGY OF BENZENE, TOLUENE, XYLENES AND PHENOLS [J].

DEAN, BJ .

MUTATION RESEARCH, 1985, 154 (03) :153-181

[7]

Dische Z., 1955, NUCLEIC ACIDS, V1

[8]

ERTURK E, 1984, P AM ASSOC CANC RES, V25, P95

[9] THE NUCLEAR-ENVELOPE AND THE ARCHITECTURE OF THE NUCLEAR PERIPHERY [J].

FRANKE, WW ;

SCHEER, U ;

KROHNE, G ;

JARASCH, ED .

JOURNAL OF CELL BIOLOGY, 1981, 91 (03) :S39-S50

[10] OXYGEN FREE-RADICALS AND IRON IN RELATION TO BIOLOGY AND MEDICINE - SOME PROBLEMS AND CONCEPTS [J].

HALLIWELL, B ;

GUTTERIDGE, JMC .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1986, 246 (02) :501-514

← 1 2 3 4 →