4',6-DIAMIDINO 2-PHENYLINDOLE IS A NEW REVERSIBLE INHIBITOR OF DIAMINE OXIDASE AND S-ADENOSYL-L-METHIONINE DECARBOXYLASE FROM MAMMALIAN-TISSUES

被引：7

作者：

CUBRIA, C

ALVAREZBUJIDOS, M

NEGRO, A

BALANAFOUCE, R

ORDONEZ, D

机构：

[1] UNIV LEON,FAC VET,DEPT FISIOL FARMACOL & TOXICOL,CAMPUS VEGAZANA,E-24071 LEON,SPAIN

[2] UNIV LEON,FAC VET,DEPT BIOQUIM & BIOL MOLEC,E-24071 LEON,SPAIN

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1993年 / 105卷 / 02期

关键词：

D O I：

10.1016/0742-8413(93)90203-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 4',6-Diamidino-2-phenylindole is a powerful reversible inhibitor of porcine kidney diamine oxidase and partially purified rabbit liver S-adenosyl-L-methionine decarboxylase. 2. This diamidine has shown to be a competitive inhibitor of porcine kidney diamine oxidase with a Ki value of 13 muM. 3. A similar inhibitory pattern has been found on rat liver S-adenosyl-L-methionine decarboxylase with an estimated Ki of 21 muM.

引用

页码：251 / 254

页数：4

共 18 条

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