ENANTIOSELECTIVE CATALYSIS .83. SYNTHESIS OF OPTICALLY-ACTIVE FERROCENYLALANINE

被引：35

作者：

BRUNNER, H ^{[1
]}

KONIG, W ^{[1
]}

NUBER, B ^{[1
]}

机构：

[1] UNIV HEIDELBERG,W-6900 HEIDELBERG,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 04期

关键词：

D O I：

10.1016/S0957-4166(00)80178-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Ferrocenylalanine, a possible substitute for phenylalanine in the commercial sweetener aspartame, was synthesized by asymmetric hydrogenation of the corresponding dehydro acylamino acids with rhodium/phosphine catalysts in up to 94% enantiomeric excess. The absolute configuration of N-benzoyl-ferrocenyl alanine 4 was determined by single-crystal X-ray analysis.

引用

页码：699 / 707

页数：9

共 28 条

[1]

[Anonymous], 1974, INT TABLES XRAY CRYS, VIV

[2] ASYMMETRIC HYDROGENATION OF (Z)-ALPHA-(ACETYLAMINO)-CINNAMIC ACID BY A RH-NORPHOS CATALYST [J].