TOTAL SYNTHESIS OF NEPHILATOXIN-8 (NPTX-8), A NEW NEUROTOXIN OF JORO SPIDER (NEPHILA-CLAVATA)

被引：11

作者：

MIYASHITA, M

MATSUSHITA, M

SATO, H

TOKI, T

NAKAJIMA, T

IRIE, H

机构：

[1] DAICEL CHEM IND LTD, RES CTR, HIMEJI 67112, JAPAN

[2] UNIV TOKYO, FAC PHARMACEUT SCI, TOKYO 113, JAPAN

来源：

CHEMISTRY LETTERS | 1993年 / 06期

关键词：

D O I：

10.1246/cl.1993.929

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first synthesis of Nephilatoxin-8 (NPTX-8), a new neurotoxin of Joro spider (Nephila clavata), has been achieved by employing two key azide intermediates for the incorporation of the characteristic polyamines of the toxin, cadaverine and spermidine.

引用

页码：929 / 932

页数：4

共 21 条

[1] EFFECTS OF A SPIDER TOXIN ON THE GLUTAMINERGIC SYNAPSE OF LOBSTER MUSCLE
ABE, T
KAWAI, N
MIWA, A
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1983, 339 (JUN): : 243 - 252
[2] STRUCTURES AND BIOLOGICAL-ACTIVITIES OF 3 SYNAPTIC ANTAGONISTS FROM ORB WEAVER SPIDER VENOM
ADAMS, ME
CARNEY, RL
ENDERLIN, FE
FU, ET
JAREMA, MA
LI, JP
MILLER, CA
SCHOOLEY, DA
SHAPIRO, MJ
VENEMA, VJ
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (02) : 678 - 683
[3] CHEMICAL CHARACTERIZATION OF SPIDER TOXIN, JS']JSTX AND NSTX
ARAMAKI, Y
YASUHARA, T
HIGASHIJIMA, T
YOSHIOKA, M
MIWA, A
KAWAI, N
NAKAJIMA, T
[J]. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1986, 62 (09): : 359 - 362
[4] SYNTHESIS OF SPIDER TOXIN (JS']JSTX-3) AND ITS ANALOGS
HASHIMOTO, Y
ENDO, Y
SHUDO, K
ARAMAKI, Y
KAWAI, N
NAKAJIMA, T
[J]. TETRAHEDRON LETTERS, 1987, 28 (30) : 3511 - 3514
[5] SPIDER TOXINS AS TOOLS FOR DISSECTING ELEMENTS OF EXCITATORY AMINO-ACID TRANSMISSION
JACKSON, H
USHERWOOD, PNR
[J]. TRENDS IN NEUROSCIENCES, 1988, 11 (06) : 278 - 283
[6] ISOLATION, STRUCTURE ELUCIDATION, AND SYNTHESIS OF NOVEL HYDROXYLAMINE-CONTAINING POLYAMINES FROM THE VENOM OF THE AGELENOPSIS-APERTA SPIDER
JASYS, VJ
KELBAUGH, PR
NASON, DM
PHILLIPS, D
ROSNACK, KJ
SACCOMANO, NA
STROH, JG
VOLKMANN, RA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (18) : 6696 - 6704
[7] THE TOTAL SYNTHESIS OF ARGIOTOXIN-636, ARGIOTOXIN-659 AND ARGIOTOXIN-673
JASYS, VJ
KELBAUGH, PR
NASON, DM
PHILLIPS, D
SACCOMANO, NA
VOLKMANN, RA
[J]. TETRAHEDRON LETTERS, 1988, 29 (48) : 6223 - 6226
[8] KAWAI N, 1984, J PHYSIOL-PARIS, V79, P228
[9] SPIDER VENOM CONTAINS SPECIFIC RECEPTOR BLOCKER OF GLUTAMINERGIC SYNAPSES
KAWAI, N
NIWA, A
ABE, T
[J]. BRAIN RESEARCH, 1982, 247 (01) : 169 - 171
[10] BLOCKADE OF SYNAPTIC TRANSMISSION IN THE SQUID GIANT SYNAPSE BY A SPIDER TOXIN (JS']JSTX)
KAWAI, N
YAMAGISHI, S
SAITO, M
FURUYA, K
[J]. BRAIN RESEARCH, 1983, 278 (1-2) : 346 - 349

← 1 2 3 →