DISCOVERY AND DEVELOPMENT OF ANTHRACYCLINE ANTITUMOR ANTIBIOTICS

被引：128

作者：

LOWN, JW

机构：

[1] Department of Chemistry, University of Alberta, Edmonton, Alta. T6G 2G2, Canada

[2] Imperial College

[3] University of Alberta, Canada

[4] Department of Organic Chemistry

[5] Alberta Her. Found. for Med. Res.

[6] International Union Against Cancer

来源：

CHEMICAL SOCIETY REVIEWS | 1993年 / 22卷 / 03期

关键词：

D O I：

10.1039/cs9932200165

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The armamentarium of the oncologist includes 40-50 clinically useful chemical agents. The paradigm of cytotoxic anticancer agents is doxorubicin, an anthracycline, which is amongst the most widely prescribed and effective of anticancer agents. This review attempts to summarize the discovery and development of the anthracyclines, their classification on the basis of structure and mechanism, and evidence on their several modes of action. Recent identification of cellular targets including topoisomerases and helicases present new challenges to the synthetic chemist and pharmacologist.

引用

页码：165 / 176

页数：12

共 39 条

[1]

ACTON EM, 1988, ANTHRACYCLINE ANTHRA, P54

[2]

ACTON EM, 1980, ANTHRACYCLINES CURRE, P15

[3] SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME 14-O-ACYL DERIVATIVES OF ADRIAMYCIN [J].

ARCAMONE, F ;

FRANCESCHI, G ;

MINGHETTI, A ;

PENCO, S ;

REDAELLI, S ;

DIMARCO, A ;

CASAZZA, AM ;

DASDIA, T ;

DIFRONZO, G ;

GUILIANI, F ;

LENAZ, L ;

NECCO, A ;

SORANZO, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (03) :335-337

[4]

ARCAMONE F, 1969, CHIM IND-MILAN, V51, P834

[5]

ARCAMONE F, 1976, Patent No. 2557537

[6]

ARCAMONE F, 1981, SERIES MONOGRAPHS, V17

[7]

Arcamone F., 1988, ANTHRACYCLINE ANTHRA, P1

[8]

BACHUR NR, 1971, J PHARMACOL EXP THER, V177, P567

[9]

BACHUR NR, 1992, MOL PHARMACOL, V41, P993

[10] RHODOMYCIN, EIN ROTES ANTIBIOTICUM AUS ACTINOMYCETEN [J].

BROCKMANN, H ;

BAUER, K .

NATURWISSENSCHAFTEN, 1950, 37 (21) :492-493

← 1 2 3 4 →