PROTECTIVE ELEVATIONS OF GLUTATHIONE AND METALLOTHIONEIN IN CADMIUM-EXPOSED MESANGIAL CELLS

被引:85
作者
CHIN, TA [1 ]
TEMPLETON, DM [1 ]
机构
[1] UNIV TORONTO, DEPT CLIN BIOCHEM, 100 COLL ST, TORONTO M5G 1L5, ONTARIO, CANADA
基金
英国医学研究理事会;
关键词
CADMIUM NEPHROTOXICITY; GLOMERULUS; MESANGIAL CELL; GLUTATHIONE; METALLOTHIONEIN;
D O I
10.1016/0300-483X(93)90145-I
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Exposure of cultured rat mesangial cells to CdCl2 caused a dose- and time-dependent increase in intracellular glutathione that was significant at 0.5 muM and maximal at 1 muM Cd2+. The effect depended on glutathione synthesis and was masked by inhibiting synthesis with buthionine sulfoximine. The cells responded to slightly higher concentrations of Cd with a marked decrease in DNA synthesis, and reversible depletion of glutathione enhanced this sensitivity. Pre-induction of the thiol-rich protein metallothionein with ZnCl2 afforded a degree of protection to the glutathione-depleted cells. We conclude that the Cd-dependent elevation of glutathione in these cells may be protective at concentrations of Cd that can arise during acute environmental and occupational exposures.
引用
收藏
页码:145 / 156
页数:12
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