EFFECT OF CALCIUM-CHANNEL BLOCKERS ON CELL-PROLIFERATION, DNA-SYNTHESIS AND COLLAGEN-SYNTHESIS OF CULTURED GINGIVAL FIBROBLASTS DERIVED FROM HUMAN NIFEDIPINE RESPONDERS AND NONRESPONDERS

被引：40

作者：

FUJII, A ^{[1
]}

MATSUMOTO, H ^{[1
]}

NAKAO, S ^{[1
]}

TESHIGAWARA, H ^{[1
]}

AKIMOTO, Y ^{[1
]}

机构：

[1] NIHON UNIV,SCH DENT,DEPT ORAL SURG 2,MATSUDO,CHIBA 271,JAPAN

来源：

ARCHIVES OF ORAL BIOLOGY | 1994年 / 39卷 / 02期

关键词：

CALCIUM-CHANNEL BLOCKERS; GINGIVAL HYPERPLASIA; GINGIVAL FIBROBLASTS;

D O I：

10.1016/0003-9969(94)90103-1

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Human gingival fibroblasts from six patients who developed gingival hyperplasia as a result of nifedipine medication and five who did not were studied for the effects of calcium-channel blockers (nifedipine, diltiazem, verapamil and nicardipine) on cell proliferation, DNA synthesis and collagen synthesis. Phenytoin was used as a positive control. The fibroblasts from reactive patients gave trends toward better cell proliferation rates, DNA synthesis ([H-3]-thymidine incorporation), and collagen synthesis ([H-3]-proline incorporation) than those from non-reactive patients in the presence of 1 muM of calcium-channel blockers or phenytoin.

引用

页码：99 / 104

页数：6

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