EFFECT OF ANTIVIRAL TREATMENTS ON THE BONE-MARROW IN MURINE AIDS

被引：4

作者：

BRANDI, G ^{[1
]}

CARNEVALI, A ^{[1
]}

ROSSI, L ^{[1
]}

FRATERNALE, A ^{[1
]}

SCHIAVANO, GF ^{[1
]}

MAGNANI, M ^{[1
]}

机构：

[1] OSPED S SALVATORE,PESARO,ITALY

来源：

BLOOD CELLS MOLECULES AND DISEASES | 1995年 / 21卷 / 02期

关键词：

BONE MARROW; CYTOPENIA; MURINE AIDS; AZT; DDC; DDCTP;

D O I：

10.1006/bcmd.1995.0013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Blood cytopenia is a common feature in HIV infection, occurring in up to 70% of patients with AIDS. Since at present it is not clear to what extent this is intrinsic to HIV infection or due to opportunistic infections and antiretroviral agents we have investigated the long-term effects of conventional and new antiviral drugs on the bone marrow of normal and immunodeficient mice. The results show that azidothymidine (AZT), dideoxycytidine (DDC) and dideoxycytidine 5'-triyhosphate (DDCTP) alone or in combination are all effective in inhibiting the expression of the retroviral protein Pr60(gag) in, bone marrow cells. However, DDCTP was the most effective in preventing bone marrow cytopenia, Combined treatments of AZT plus DDCTP result in a reduction in erythroid precursors compared to that resulting from DDCTP administration, while DDC plus DDCTP results in a differential cell count similar to that found in uninfected mice. Thus, the bone marrow in murine AIDS may prove useful as a model for therapy of retroviral infections and for treating blood cytopenias.

引用

页码：109 / 118

页数：10

共 29 条

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