SYNERGY BETWEEN BASIC FIBROBLAST GROWTH-FACTOR AND HIV-I TAT PROTEIN IN INDUCTION OF KAPOSIS-SARCOMA

被引:514
作者
ENSOLI, B
GENDELMAN, R
MARKHAM, P
FIORELLI, V
COLOMBINI, S
RAFFELD, M
CAFARO, A
CHANG, HK
BRADY, JN
GALLO, RC
机构
[1] NCI,MOLEC VIROL LAB,BETHESDA,MD 20892
[2] ADV BIOSCI LABS INC,KENSINGTON,MD 20895
[3] HENRY M JACKSON FDN,ROCKVILLE,MD 20850
关键词
D O I
10.1038/371674a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.
引用
收藏
页码:674 / 680
页数:7
相关论文
共 43 条
[1]   TUMOR-CELL INVASION INHIBITED BY TIMP-2 [J].
ALBINI, A ;
MELCHIORI, A ;
SANTI, L ;
LIOTTA, LA ;
BROWN, PD ;
STETLERSTEVENSON, WG .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (11) :775-779
[2]  
ALBINI A, IN PRESS P NATN ACAD
[3]   THE TAT PROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, A GROWTH-FACTOR FOR AIDS KAPOSI-SARCOMA AND CYTOKINE-ACTIVATED VASCULAR CELLS, INDUCES ADHESION OF THE SAME CELL-TYPES BY USING INTEGRIN RECEPTORS RECOGNIZING THE RGD AMINO-ACID-SEQUENCE [J].
BARILLARI, G ;
GENDELMAN, R ;
GALLO, RC ;
ENSOLI, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7941-7945
[4]  
BARILLARI G, 1992, J IMMUNOL, V149, P3727
[5]   REQUIREMENT OF VASCULAR INTEGRIN ALPHA(V)BETA(3) FOR ANGIOGENESIS [J].
BROOKS, PC ;
CLARK, RAF ;
CHERESH, DA .
SCIENCE, 1994, 264 (5158) :569-571
[6]   EFFECTS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TAT PROTEIN ON THE EXPRESSION OF INFLAMMATORY CYTOKINES [J].
BUONAGURO, L ;
BARILLARI, G ;
CHANG, HK ;
BOHAN, CA ;
KAO, V ;
MORGAN, R ;
GALLO, RC ;
ENSOLI, B .
JOURNAL OF VIROLOGY, 1992, 66 (12) :7159-7167
[7]   THE HEPARIN-BINDING (FIBROBLAST) GROWTH-FACTOR FAMILY OF PROTEINS [J].
BURGESS, WH ;
MACIAG, T .
ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 :575-606
[8]  
COLLIER IE, 1988, J BIOL CHEM, V263, P6579
[9]  
CORDONCARDO C, 1990, LAB INVEST, V63, P832
[10]   TAT PROTEIN OF HIV-1 STIMULATES GROWTH OF CELLS DERIVED FROM KAPOSIS-SARCOMA LESIONS OF AIDS PATIENTS [J].
ENSOLI, B ;
BARILLARI, G ;
SALAHUDDIN, SZ ;
GALLO, RC ;
WONGSTAAL, F .
NATURE, 1990, 345 (6270) :84-86