EFFECTS OF METAL IONS ON ACTION POTENTIALS OF LOBSTER GIANT AXONS

被引：21

作者：

HAFEMANN, DR

机构：

[1] Department of Chemistry, University of California, San Diego, La Jolla

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY | 1969年 / 29卷 / 03期

基金：

美国国家卫生研究院;

关键词：

cadmium; calcium; cobalt; lanthanum; Lobster axon; manganese; nerve ions; nickel; Panulirus interruptusl magnesium; strontium; zinc;

D O I：

10.1016/0010-406X(69)91019-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. In the absence of CaII or other polyvalent cations, Panulirus interruptus giant axons are inexcitable. 2. 2. The divalent ions MgII, SrII, BaII, MnII, FeII, CoII, NiII, ZnII and CdII substitute for calcium, with varying effectiveness. 3. 3. The trivalent ions LaIII, YIII and all of the lanthanides substitute for calcium, but cause a lengthening of the spike. 4. 4. The ions PtIV, PdII, AgI, AuIII, CdII, HgII and PbII are toxic at pH 7·5, even in the presence of calcium. 5. 5. The binding site for metals is an oxygen ligand, possibly phosphate. © 1969.

引用

页码：1149 / &

共 27 条

[1] INTERACTIONS OF CALCIUM WITH SODIUM AND POTASSIUM IN MEMBRANE POTENTIALS OF THE LOBSTER GIANT AXON [J].