DECARBOXYLATIVE CARBON ACYLATION OF MALONATES WITH AMINOACYLIMIDAZOLIDES MEDIATED BY LEWIS-ACIDS

被引：23

作者：

MANSOUR, TS

EVANS, CA

机构：

[1] Institut Armand-Frappier, Industrial Chair, Laval, Quebec, H7V 1B7, Bldg. 22

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1080/00397919008052321

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various N-protected aminoacyl imidazolides undergo decarboxylative carbon acylation with sodium or potassium monomethylmalonate in THF in the presence of MgCl2, CoCl2 or MnCl2to give dipeptide analogues (3) in 45-82% isolated yield. Amino Ketoester (3e) undergoes intramolecular cyclization induced by diisopropylethylamine and anhydrous magnesium chloride to trisubstituted tetramic acid (4). © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：773 / 781

页数：9

共 13 条

[1] C-ACYLATION UNDER VIRTUALLY NEUTRAL CONDITIONS [J].