THE EFFECT OF GAMMA-HYDROXYBUTYRATE ON NOCTURNAL AND DIURNAL SLEEP OF NORMAL SUBJECTS - FURTHER CONSIDERATIONS ON REM SLEEP-TRIGGERING MECHANISMS

被引：66

作者：

LAPIERRE, O ^{[1
]}

MONTPLAISIR, J ^{[1
]}

LAMARRE, M ^{[1
]}

BEDARD, MA ^{[1
]}

机构：

[1] HOP SACRE COEUR, CTR ETUD SOMMEIL, 5400 BLVD GOUIN OUEST, MONTREAL H4J 1C5, QUEBEC, CANADA

来源：

SLEEP | 1990年 / 13卷 / 01期

关键词：

GHB; Hypothalamus; Nap; REM sleep;

D O I：

10.1093/sleep/13.1.24

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Gamma-hydroxybutyrate (GHB) is a drug currently used to treat narcolepsy. The present study documents its effect on sleep organization in healthy subjects. GHB and a placebo were given at bedtime and before a morning nap in a double-blind fashion. GHB administered before nocturnal or diurnal sleep increases stages 3 and 4 and decreases stage 1 non-rapid eye movement (NREM) sleep. In addition, GHB improves REM efficiency at night and reduces wake time after sleep onset when administered before a morning nap recording. GHB also slightly decreases REM latency when administered in the morning, and this effect is correlated with age. Hypotheses regarding mechanisms of action of GHB and the involvement of hypothalamic structures in the regulation of REM sleep are discussed.

引用

页码：24 / 30

页数：7

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