NA+-DEPENDENT CA-2+ EFFLUX INHIBITS STIMULUS-INDUCED SECRETION IN BOVINE CHROMAFFIN CELLS

被引：13

作者：

GOH, Y

KUROSAWA, A

机构：

[1] Shionogi Research Laboratories, Shionogi and Co., Ltd., Fukushima-ku, Osaka

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)91014-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stimulations of chromaffin cells with histamine and ionomycin produced rises in cellular free Ca2+ level. The removal of Na+ ions from the medium prolongated the rises without changing the magnitude. The stimulations also facilitated 45Ca2+ efflux from cells by over 3-fold. The facilitation was, however, largely abolished by the Na+ removal, indicating the Na+-dependent efflux is a major system to expel Ca2+ from the stimulated cells. The Na+ removal also enhanced secretions evoked by these stimuli. The results suggest the Na+-dependent Ca2+ efflux by lowering the elevated cellular Ca2+ plays a role in terminating the stimulus-induced secretion. © 1990.

引用

页码：1346 / 1351

页数：6

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