IMBALANCE IN X-CHROMOSOME EXPRESSION - EVIDENCE FOR A HUMAN X-LINKED GENE AFFECTING GROWTH OF HEMATOPOIETIC-CELLS

被引：41

作者：

LUZZATTO, L

USANGA, EA

BIENZLE, U

ESAN, GFJ

FASUAN, FA

机构：

[1] UNIV COLL HOSP IBADAN,DEPT HEMATOL,IBADAN,NIGERIA

[2] BERNHARD NOCHT INST SCHIFFS & TROPENKRANKHEITEN,D-2000 HAMBURG 4,FED REP GER

来源：

SCIENCE | 1979年 / 205卷 / 4413期

关键词：

D O I：

10.1126/science.472761

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In each of six family members who were heterozygous at the X-linked locus for glucose-6-phosphate dehydrogenase, only one or the other of the two alleles at that locus was almost exclusively expressed. The data are consistent with evidence that X-chromosome inactivation is a random process that may be followed by selection for one of the two resulting cell types on the basis of an unknown gene, which is located on the X chromosome and which can affect the rate of proliferation of hemopoietic cells in humans.

引用

页码：1418 / 1420

页数：3

共 29 条

[1] NORMAL HUMAN FEMALE AS A MOSAIC OF X-CHROMOSOME ACTIVITY - STUDIES USING GENE FOR G-6-PD-DEFICIENCY AS A MARKER [J].