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CYSTATINS - INHIBITORS OF CYSTEINE PROTEINASES
被引：128
作者：
BOBEK, LA
LEVINE, MJ
机构：
[1] Oral Biol. Dept./Dental Res. Inst., School of Dental Medicine, State University of New York, Buffalo
关键词：
CYSTEINE PROTEINASES;
CYSTATINS;
SALIVA;
PROTEIN STRUCTURE;
FUNCTION;
GENETICS;
D O I：
10.1177/10454411920030040101
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The cystatin superfamily of proteins, derived from a common ancestor, is comprised of a diverse group of potent cysteine proteinase inhibitors and antibacterial/viral agents grouped into several families. This review concentrates on family 2 cystatins, namely, the human salivary cystatins and cystatin C. Emphasis is given to their physicochemical and functional properties at both the protein and the molecular level. The role of cystatins in disease processes, including those in the oral cavity, is also discussed. Finally, future directions for cystatin research in oral biology are presented.
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页码：307 / 332
页数：26
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