ATPENINS, NEW ANTIFUNGAL ANTIBIOTICS PRODUCED BY PENICILLIUM SP - PRODUCTION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：43

作者：

OMURA, S

TOMODA, H

KIMURA, K

ZHEN, DZ

KUMAGAI, H

IGARASHI, K

IMAMURA, N

TAKAHASHI, Y

TANAKA, Y

IWAI, Y

机构：

[1] KITASATO UNIV, KITASATO INST MINATO KU, TOKYO 108, JAPAN

[2] KITASATO UNIV, SCH PHARMACEUT SCI, MINATO KU, TOKYO 108, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1988年 / 41卷 / 12期

关键词：

D O I：

10.7164/antibiotics.41.1769

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Penicillium sp. FO-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin. Three components A4, A5 and B were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and HPLC. The molecular formula of atpenins A4, A5 and B were determined to be C15H22NO5Cl, C15H21H21NO5Cl2 and C15H23NO3, respectively, on the basis of high resolution electron impact mass spectrometry and elemental analysis. They are active against filamentous fungi, especially, Trichophyton sp.

引用

页码：1769 / 1774

页数：6