INTERACTION OF INDOMETHACIN AND SULINDAC WITH LABETALOL

被引：8

作者：

ABATE, MA ^{[1
]}

NEELY, JL ^{[1
]}

LAYNE, RD ^{[1
]}

DALESSANDRI, R ^{[1
]}

机构：

[1] W VIRGINIA UNIV,SCH MED,MORGANTOWN,WV 26506

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 31卷 / 03期

关键词：

INDOMETHACIN; SULINDAC; LABETALOL; INTERACTION;

D O I：

10.1111/j.1365-2125.1991.tb05546.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of sulindac and indomethacin on the blood pressure response to labetalol were determined in well-controlled predominantly obese hypertensive patients (n = 26). A stabilized dose of labetalol alone was administered on weeks 1 and 3, and either indomethacin or sulindac was administered with labetalol on week 2, with cross-over to the other drug on week 4. Indomethacin and sulindac increased the sitting and standing systolic blood pressure (BP) to a statistically significant extent compared with placebo. The effects of indomethacin on systolic BP, diastolic BP, and weight were not significantly different from those with sulindac. Indomethacin but not sulindac produced minor increases in diastolic BP and weight compared with placebo.

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收藏

页码：363 / 366

页数：4

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