GENE STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE

被引：41

作者：

KADOYA, A ^{[1
]}

TONE, S ^{[1
]}

MAEDA, H ^{[1
]}

MINATOGAWA, Y ^{[1
]}

KIDO, R ^{[1
]}

机构：

[1] WAKAYAMA MED COLL,DEPT BIOCHEM,27 KYUBANCHO,WAKAYAMA 640,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91590-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two genomic DNA clones that encode human indoleamine 2,3-dioxygenase (IDO) were isolated from the human genomic DNA library using the IDO cDNA as a probe, and their restriction maps and partial nucleotide sequences were determined. The human IDO gene spanned 15 kilobase pairs with ten exons. The 5′ terminus of the IDO mRNA was 33 nucleotides upstream of the translation initiation codon ATG. The 5′ flanking region contained ISRE, X-box, and Y-box like sequences. Southern blot analysis of the human genomic DNA indicated that the human IDO gene was present in a single copy in the genome. © 1992.

引用

页码：530 / 536

页数：7

共 23 条

[1] REGULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II GENES - X, Y AND OTHER LETTERS OF THE ALPHABET
BENOIST, C
MATHIS, D
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 : 681 - 715
[2] BONNEM EM, 1987, J BIOL RESP MODIF, V6, P275
[3] DAI W, 1990, J BIOL CHEM, V265, P19871
[4] CONSERVED MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II BOX-X AND BOX-Y ARE TRANSCRIPTIONAL CONTROL ELEMENTS AND SPECIFICALLY BIND NUCLEAR PROTEINS
DORN, A
DURAND, B
MARFING, C
LEMEUR, M
BENOIST, C
MATHIS, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (17) : 6249 - 6253
[5] FLECKNER J, 1991, P NATL ACAD SCI US, V88
[6] GREENE JM, 1987, CURRENT PROTOCOLS MO
[7] HAYAISHI O, 1975, 10TH P FEBS M, P131
[8] A HARVEY-RAS RESPONSIVE TRANSCRIPTION ELEMENT IS ALSO RESPONSIVE TO A TUMOR-PROMOTER AND TO SERUM
IMLER, JL
SCHATZ, C
WASYLYK, C
CHATTON, B
WASYLYK, B
[J]. NATURE, 1988, 332 (6161) : 275 - 278
[9] PURIFIED TRANSCRIPTION FACTOR AP-1 INTERACTS WITH TPA-INDUCIBLE ENHANCER ELEMENTS
LEE, W
MITCHELL, P
TJIAN, R
[J]. CELL, 1987, 49 (06) : 741 - 752
[10] REGULATED EXPRESSION OF A GENE ENCODING A NUCLEAR FACTOR, IRF-1, THAT SPECIFICALLY BINDS TO IFN-BETA-GENE REGULATORY ELEMENTS
MIYAMOTO, M
FUJITA, T
KIMURA, Y
MARUYAMA, M
HARADA, H
SUDO, Y
MIYATA, T
TANIGUCHI, T
[J]. CELL, 1988, 54 (06) : 903 - 913

← 1 2 3 →