METABOLIC N-HYDROXYLATION - USE OF SUBSTITUENT VARIATION TO MODULATE THE INVITRO BIOACTIVATION OF 4-ACETAMIDOSTILBENES

被引:13
作者
HANNA, PE [1 ]
GAMMANS, RE [1 ]
SEHON, RD [1 ]
LEE, MK [1 ]
机构
[1] UNIV MINNESOTA,DEPT PHARMACOL,MINNEAPOLIS,MN 55455
关键词
D O I
10.1021/jm00183a014
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1038 / 1044
页数:7
相关论文
共 31 条
[1]  
ARIENS EJ, 1977, DRUG DESIGN ADVERSE, P329
[2]  
ARIENS EJ, 1980, DRUG DES, V9, P30
[3]   WHAT LIMITS RATE OF AN ENZYME-CATALYZED REACTION [J].
CLELAND, WW .
ACCOUNTS OF CHEMICAL RESEARCH, 1975, 8 (05) :145-151
[4]   MIGRATION OF DEUTERIUM DURING HYDROXYLATION OF AROMATIC SUBSTRATES BY LIVER MICROSOMES .I. INFLUENCE OF RING SUBSTITUENTS [J].
DALY, J ;
JERINA, D ;
WITKOP, B .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1968, 128 (02) :517-&
[5]  
GAMMANS RE, 1977, DRUG METAB DISPOS, V5, P310
[6]  
GAMMANS RE, 1978, DRUG METAB DISPOS, V6, P226
[7]   RELATIONSHIP BETWEEN THE LIPID SOLUBILITY OF DRUGS AND THEIR OXIDATION BY LIVER MICROSOMES [J].
GAUDETTE, LE ;
BRODIE, BB .
BIOCHEMICAL PHARMACOLOGY, 1959, 2 (02) :89-96
[8]  
HANSCH C, 1973, DRUG METAB REV, V1, P1
[9]  
HARFENIST M, J MED CHEM
[10]  
HJELMELAND LM, 1977, MOL PHARMACOL, V13, P634