METAL ION-PROMOTED HYDROLYSIS OF URIDINE 2',3'-CYCLIC MONOPHOSPHATE - EFFECT OF METAL-CHELATES AND UNCOMPLEXED AQUO IONS

被引：31

作者：

KUUSELA, S ^{[1
]}

LONNBERG, H ^{[1
]}

机构：

[1] UNIV TURKU,DEPT CHEM,SF-20500 TURKU 50,FINLAND

来源：

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY | 1992年 / 5卷 / 12期

关键词：

D O I：

10.1002/poc.610051205

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The effect of a wide variety of metal ions and metal ion complexes on the hydrolysis of uridine 2',3'-cyclic monophosphate was studied over the pH range 4.5-8.0. The greatest rate accelerations observed were 10(7)-10(8)-fold. The kinetic data obtained are interpreted in terms of a mechanism involving a rapid monodentate binding of the metal ion to the monoanionic phosphodiester and a subsequent intracomplex participation of the metal-bound hydroxo ligand, either as a nucleophile attacking the tetracoordinated phosphorus or as a base facilitating an intermolecular attack of a water molecule. No effect on the product distribution between uridine 2'- and 3'-monophosphates was observed.

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页码：803 / 811

页数：9

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