INCREASED APOPTOSIS IN THE CINGULATE SULCUS OF NEWBORN PIGLETS FOLLOWING TRANSIENT HYPOXIA-ISCHEMIA IS RELATED TO THE DEGREE OF HIGH-ENERGY PHOSPHATE-DEPLETION DURING THE INSULT

被引：105

作者：

MEHMET, H

YUE, X

SQUIER, MV

LOREK, A

CADY, E

PENRICE, J

SARRAF, C

WYLEZINSKA, M

KIRKBRIDE, V

COOPER, C

BROWN, GC

WYATT, JS

REYNOLDS, EOR

EDWARDS, AD

机构：

[1] ROYAL POSTGRAD MED SCH, DEPT PAEDIAT & NEONATAL MED, LONDON W12 0NN, ENGLAND

[2] ROYAL POSTGRAD MED SCH, DEPT HISTOPATHOL, LONDON, ENGLAND

[3] UCL, DEPT PAEDIAT, LONDON, ENGLAND

[4] UCL, DEPT BIOCHEM, LONDON, ENGLAND

[5] UCL HOSP TRUST, DEPT MED PHYS & BIOENGN, LONDON, ENGLAND

[6] RADCLIFFE INFIRM, DEPT NEUROPATHOL, OXFORD OX2 6HE, ENGLAND

来源：

NEUROSCIENCE LETTERS | 1994年 / 181卷 / 1-2期

基金：

英国惠康基金;

关键词：

APOPTOSIS; BRAIN; CEREBRAL; HYPOXIA; ISCHEMIA; NEONATE; PIGLET; IN SITU END LABELING; MAGNETIC RESONANCE SPECTROSCOPY;

D O I：

10.1016/0304-3940(94)90574-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An increase in the number of cells undergoing apoptosis was observed in the cingulate sulcus of newborn piglets 48 h after a global hypoxic-ischaemic insult. Apoptotic death was identified morphologically (by light and electron microscopy) and by DNA fragmentation, detected by in situ end labelling. The number of apoptotic cells was directly related to the degree of high-energy phosphate depletion during hypoxia-ischaemia, measured using continuous P-31 magnetic resonance spectroscopy. These results may have implications for the understanding and treatment of perinatal hypoxic-ischaemic brain injury.

引用

页码：121 / 125

页数：5

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