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THE CD19-CR-2-TAPA-1 COMPLEX, CD45 AND SIGNALING BY THE ANTIGEN RECEPTOR OF B-LYMPHOCYTES

被引：76
作者：
FEARON, DT [1 ]
机构：
[1] UNIV CAMBRIDGE,SCH CLIN MED,CAMBRIDGE,ENGLAND
来源：
CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 03期
关键词：
D O I：
10.1016/0952-7915(93)90051-S
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A paradigm describing the response of T lymphocytes to antigen holds that signals from antigen receptors must be modulated by non-antigen-specific, accessory membrane proteins for an appropriate cellular response to occur, such as differentiation, activation and tolerance. Recent studies suggest that this paradigm applies also to B lymphocytes. Signaling through membrane IgM in these cells requires CD45, a phosphotyrosine phosphatase, and is amplified by a complex containing CD19, complement receptor 2 (CD21), and TAPA-1, which recruits the intracellular enzyme, phosphatidylinositol 3-kinase.
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页码：341 / 348
页数：8
相关论文
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