DOES IRON PLAY A ROLE IN PARKINSONS-DISEASE

被引：14

作者：

BAUMINGER, ER

BARCIKOWSKA, M

FRIEDMAN, A

GALAZKAFRIEDMAN, J

HECHEL, D

NOWIK, I

机构：

[1] MED ACAD WARSAW,DEPT NEUROL,WARSAW,POLAND

[2] WARSAW UNIV TECHNOL,INST PHYS,WARSAW,POLAND

来源：

HYPERFINE INTERACTIONS | 1994年 / 91卷 / 1-4期

关键词：

D O I：

10.1007/BF02064618

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Mossbauer studies of Parkinsonian and control Substantia Nigra (SN) show that the overall amount of iron in SN is about the same in PD and control. At least 90% of this iron is ferritin-like and Fe2+ and/or neuromelanin iron, if present at all, can constitute only less than 10% of the overall iron. During storage in formalin, iron is slowly removed from ferritin and bound to a chelating agent.

引用

页码：853 / 857

页数：5

共 7 条

[1] COMPARATIVE MOSSBAUER AND INFRARED-ANALYSIS OF IRON-CONTAINING MELANINS
BARDANI, L
BRIDELLI, MG
CARBUCICCHIO, M
CRIPPA, PR
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 716 (01) : 8 - 15
[2] MOSSBAUER SPECTROSCOPIC INVESTIGATION OF STRUCTURE-FUNCTION RELATIONS IN FERRITINS
BAUMINGER, ER
HARRISON, PM
HECHEL, D
NOWIK, I
TREFFRY, A
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1118 (01) : 48 - 58
[3] MOSSBAUER SPECTROSCOPIC STUDIES OF HUMAN HEMOSIDERIN AND FERRITIN
BELL, SH
WEIR, MP
DICKSON, DPE
GIBSON, JF
SHARP, GA
PETERS, TJ
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 787 (03) : 227 - 236
[4] IRON MELANIN COMPLEX IN SUBSTANTIA-NIGRA OF PARKINSONIAN BRAINS - AN X-RAY-MICROANALYSIS
JELLINGER, K
KIENZL, E
RUMPELMAIR, G
RIEDERER, P
STACHELBERGER, H
BENSHACHAR, D
YOUDIM, MBH
[J]. JOURNAL OF NEUROCHEMISTRY, 1992, 59 (03) : 1168 - 1171
[5] BRAIN IRON AND FERRITIN IN PARKINSONS AND ALZHEIMERS DISEASES
JELLINGER, K
PAULUS, W
GRUNDKEIQBAL, I
RIEDERER, P
YOUDIM, MBH
[J]. JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION, 1990, 2 (04) : 327 - 340
[6] INCREASED IRON(III) AND TOTAL IRON CONTENT IN POST-MORTEM SUBSTANTIA NIGRA OF PARKINSONIAN BRAIN
SOFIC, E
RIEDERER, P
HEINSEN, H
BECKMANN, H
REYNOLDS, GP
HEBENSTREIT, G
YOUDIM, MBH
[J]. JOURNAL OF NEURAL TRANSMISSION, 1988, 74 (03) : 199 - 205
[7] REGIONAL METAL CONCENTRATIONS IN PARKINSONS-DISEASE, OTHER CHRONIC NEUROLOGICAL DISEASES, AND CONTROL BRAINS
UITTI, RJ
RAJPUT, AH
ROZDILSKY, B
BICKIS, M
WOLLIN, T
YUEN, WK
[J]. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1989, 16 (03) : 310 - 314

← 1 →