EFFECT OF TOPICAL CRUDE COAL-TAR TREATMENT ON UNSTIMULATED HAIRLESS HAMSTER SKIN

被引：12

作者：

FOREMAN, MI

PICTON, W

LUKOWIECKI, GA

CLARK, C

机构：

[1] Department of Chemical Pharmacology, Scientific Development Group, Organon Laboratories Limited, Newhouse, Lanarkshire

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1979年 / 100卷 / 06期

关键词：

D O I：

10.1111/j.1365-2133.1979.tb08077.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Topical treatment of hairless hamster skin with crude coal tar has been shown to induce epidermal thickening, an increased labelling index in the basal cell layer, an elevation in NADP‐dependent glucose‐6‐phosphate dehydrogenasc activity throughout the epidermis, an increased squame count, comedo formation, and atrophy of the sebaceous glands. Ultraviolet light fluorescence microscopy of sections of treated skin suggests that the hair follicle is an important route for skin penetration by coal tar. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：707 / 715

页数：9

共 7 条

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[5] CRUDE COAL-TAR PLUS NEAR ULTRAVIOLET-LIGHT SUPPRESSES DNA-SYNTHESIS IN EPIDERMIS
STOUGHTON, RB
DEQUOY, P
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[J]. ARCHIVES OF DERMATOLOGY, 1978, 114 (01) : 43 - 45
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