TECHNOLOGICAL EVALUATION OF 3 ENTERIC COATING POLYMERS .2. WITH A SOLUBLE DRUG

被引：2

作者：

KANE, Y ^{[1
]}

RAMBAUD, J ^{[1
]}

MAILLOLS, H ^{[1
]}

LAGET, JP ^{[1
]}

GAUDY, D ^{[1
]}

DELONCA, H ^{[1
]}

机构：

[1] FAC PHARM MONTPELLIER,F-34060 MONTPELLIER,FRANCE

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1994年 / 20卷 / 06期

关键词：

D O I：

10.3109/03639049409038348

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Three enteric coating polymers, cellulose acetate phthalate (CAP), hydroxy propylmethylcellulose phthalate (HP55) and cellulose acetate trimellitate (CAT) were evaluated on two different chemical substrates (soluble and insoluble). Gastric juice resistance was tested by dissolution using USP apparatus (paddle) in Britton buffer at different pH, under sink conditions over 5 hours. It-can be said that the resistance of tablets depends on the coating formulation considered and the drug solubility. From our tests it results that CAP is more resistant than CAT for two drugs in intestinal medium and the resistance of HP55 depends on the solubility of the drugs. More, only CAT allows the release in the proximal small intestine for drugs whatever solubiliy.

引用

页码：1021 / 1034

页数：14

共 8 条

[1]

BENHALIMA N, 1988, THESIS MMONTPELLIER

[2]

TECHNOLOGICAL EVALUATION OF AQUEOUS ENTERIC COATING SYSTEMS WITH AND WITHOUT INSOLUBLE ADDITIVES [J].