ENZYMATIC RESOLUTION OF 1,2-DIOLS - PREPARATION OF OPTICALLY PURE DROPROPIZINE

被引：49

作者：

BIANCHI, D

BOSETTI, A

CESTI, P

GOLINI, P

机构：

[1] Istituto Guido Donegani, 28100 Novara

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 22期

关键词：

LIPASE; STEREOSELECTIVE ALCHOLYSIS; 1,2-DIOLS; DROPROPIZINE; ENZYMES IN ORGANIC SOLVENT;

D O I：

10.1016/S0040-4039(00)79859-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Kinetic resolution of (R,S)-3-(4-phenyl-1-piperazinyl)1,2-propanediol diacetate (2) by alcoholysis with n-propanol was carried out under lipase Amano PS catalysis in various organic solvents. Pure enantiomers of the corresponding diol (1) are useful as antitussive and central sedative therapeutic agents.

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页码：3231 / 3234

页数：4

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