CARRAGEENAN-INDUCED INFLAMMATION OF THE HIND FOOT PROVOKES A RISE OF GABA-IMMUNOREACTIVE CELLS IN THE RAT SPINAL-CORD THAT IS PREVENTED BY PERIPHERAL NEURECTOMY OR NEONATAL CAPSAICIN TREATMENT

被引：69

作者：

CASTROLOPES, JM

TAVARES, I

TOLLE, TR

COIMBRA, A

机构：

[1] FAC MED OPORTO, INST HISTOL & EMBRYOL, P-4200 OPORTO, PORTUGAL

[2] MAX PLANCK INST PSYCHIAT, DEPT CLIN NEUROPHARMACOL, W-8000 MUNICH 40, GERMANY

来源：

PAIN | 1994年 / 56卷 / 02期

关键词：

GAMMA-AMINOBUTYRIC ACID; INFLAMMATORY PAIN; CARRAGEENAN; CAPSAICIN; SPINAL CORD; (RAT);

D O I：

10.1016/0304-3959(94)90094-9

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

An increase in the number of gamma-aminobutyric acid (GABA)-immunoreactive cells is reported in the superficial dorsal horn of the rat spinal cord upon unilateral inflammation of the hind foot caused by subcutaneous carrageenan injection. The rise of GABAergic cells was restricted to the ipsilateral dorsal horn, reaching a peak value of 23.4% over the contralateral side 4 days after carrageenan injection. Sciatic neurectomy or neonatal capsaicin treatment prevented this effect. These findings suggest that dorsal horn GABA is up-regulated by the increase of noxious inflow conveyed by unmyelinated C fibers from the inflamed tissues.

引用

页码：193 / 201

页数：9

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