EFFECT OF METAL COUNTERIONS ON THE STEREOSELECTIVITY OF ALDOL REACTIONS USED TO ASSEMBLE THE SECO ACID BACKBONE OF ERYTHROMYCIN-B

被引：18

作者：

MARTIN, SF

LEE, WC

机构：

[1] Department of Chemistry and Biochemistry, The University of Texas, Austin

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)73542-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diastereofacial selectivity of the aldol reactions of the enolates derived from the ketones 11, 15, and 19 with the aldehyde 2a depended upon whether the counterion was lithium or titanium. For lithium enolates the stereoselectivity appeared to be controlled by the stereochemistry alpha to the carbonyl group of the aldehyde partner, whereas the stereochemistry at the alpha'-carbon of the enolate was important for the titanium enolate.

引用

页码：2711 / 2714

页数：4

共 34 条

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