PREVALENCE OF NEWLY ISOLATED, CYTOPATHIC SMALL ROUND VIRUS (AICHI STRAIN) IN JAPAN

被引:83
作者
YAMASHITA, T
SAKAE, K
ISHIHARA, Y
ISOMURA, S
UTAGAWA, E
机构
[1] NAGOYA UNIV,SCH MED,SHOWA KU,NAGOYA,AICHI 466,JAPAN
[2] NATL INST HLTH,SHINJUKU KU,TOKYO 162,JAPAN
关键词
D O I
10.1128/JCM.31.11.2938-2943.1993
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Cytopathic small round virus (Aichi strain), isolated from a patient with oyster-associated gastroenteritis, showed no reaction in the polymerase chain reaction method for enteroviruses or in the enzyme-linked immunosorbent assay (ELISA) for the five serotypes of astroviruses. Our ELISA was sensitive in detecting the Aichi strain antigen in stool samples, but there was no reaction in this ELISA with any non-Aichi strains of enteric viruses, with such origins as enterovirus, rotavirus, Norwalk virus, calicivirus, or astrovirus. In the ELISA, 13 of 47 stool samples from adult patients in five of nine oyster-associated gastroenteritis outbreaks were positive, but only 1 of 397 pediatric stool samples in Aichi Prefecture was positive. The prevalence rate for Aichi strain antibody was found to be 7.2% for persons aged 7 months to 4 years. The prevalence rate for antibody to Aichi strain increased with age, to about 80% in persons 35 years old. On the basis of the results of the present study, it was hypothesized that Aichi strain could be a new type of small round virus that mainly produces diarrhea in patients in the 15- to 34-year-old age group, 50 to 76% of whom possess neutralizing antibody.
引用
收藏
页码:2938 / 2943
页数:6
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