ANTIBODY-PRODUCTION SYSTEM MODULATED BY ORAL-ADMINISTRATION OF HUMAN-MILK AND TGF-BETA

被引：30

作者：

ISHIZAKA, S ^{[1
]}

KIMOTO, M ^{[1
]}

TSUJII, T ^{[1
]}

SAITO, S ^{[1
]}

机构：

[1] NARA MED UNIV,DEPT OBSTET & GYNECOL,KASHIHARA,NARA 634,JAPAN

来源：

CELLULAR IMMUNOLOGY | 1994年 / 159卷 / 01期

关键词：

D O I：

10.1006/cimm.1994.1296

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human milk contains large amounts of transforming growth factor-beta (TGF-beta), which exerts powerful suppressive effects on many immune functions. Oral administration of human milk and TGF-beta in mice strongly inhibited anti-sheep red blood cell (SRBC) responses obtained following oral immunization with SRBC, but enhanced the responses elicited by intraperitoneal, intrabronchial or intravenous immunization with SRBC. Anti-SRBC antibody responses stimulated by intraperitoneal or intravenous immunization with SRBC failed to augment when TGF-beta-depleted human milk was given orally. These findings suggest that TGF-beta in human milk functions as an adjuvant for protective antibody responses against parenteral infections. (C) 1994 Academic Press, Inc.

引用

页码：77 / 84

页数：8

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