STEREOSPECIFIC CONTROL OF THE CITRATE SYNTHASE MEDIATED SYNTHESIS OF (2R,3R)-3-FLUOROCITRATE BY THE RELATIVE STABILITIES OF THE INTERMEDIATE FLUOROENOLATES

被引：11

作者：

OHAGAN, D ^{[1
]}

RZEPA, HS ^{[1
]}

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT CHEM,LONDON SW7 2AY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 18期

关键词：

D O I：

10.1039/c39940002029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A model for the stereochemical course of enzymatically mediated condensations involving fluoroacetyl-CoA is provided by ab initio calculations of the relative stabilities of the E- and Z-isomers of fluorothioacyl enols and enolates, in which we suggest the enolate intermediate is substantially protonated for citrate synthase but not for malate synthase.

引用

页码：2029 / 2030

页数：2

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