H-1-NMR STUDY OF DEGRADATION MECHANISMS OF OXACEPHEM DERIVATIVES WITH VARIOUS 3'-SUBSTITUENTS IN ALKALINE-SOLUTION

被引：20

作者：

NISHIKAWA, J ^{[1
]}

WATANABE, F ^{[1
]}

SHUDOU, M ^{[1
]}

TERUI, Y ^{[1
]}

NARISADA, M ^{[1
]}

机构：

[1] SHIONOGI & CO LTD,SHIONOGI RES LAB,FUKUSHIMA KU,OSAKA 553,JAPAN

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 03期

关键词：

D O I：

10.1021/jm00386a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：523 / 527

页数：5

共 28 条

[1]

ANDERSON EG, 1983, J BIOL CHEM, V258, P3120

[2]

ANDERSON EG, 1981, J BIOL CHEM, V256, P1401

[3] ELECTRONIC-STRUCTURES OF CEPHALOSPORINS AND PENICILLINS .15. INDUCTIVE EFFECT OF THE 3-POSITION SIDE-CHAIN IN CEPHALOSPORINS [J].

BOYD, DB .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (01) :63-66

[4] SUBSTITUENT EFFECTS IN CEPHALOSPORINS AS ASSESSED BY MOLECULAR-ORBITAL CALCULATIONS, NUCLEAR MAGNETIC-RESONANCE, AND KINETICS [J].

BOYD, DB .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (07) :1010-1013

[5] ELECTRONIC-STRUCTURES OF CEPHALOSPORINS AND PENICILLINS .11. PARABOLIC RELATIONSHIPS BETWEEN ANTI-BACTERIAL ACTIVITY OF CEPHALOSPORINS AND BETA-LACTAM REACTIVITY PREDICTED FROM MOLECULAR-ORBITAL CALCULATIONS [J].

BOYD, DB ;

HERRON, DK ;

LUNN, WHW ;

SPITZER, WA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (06) :1812-1814

[6] SUBSTITUENT EFFECTS ON REACTIVITY AND SPECTRAL PARAMETERS OF CEPHALOSPORINS [J].

COENE, B ;

SCHANCK, A ;

DEREPPE, JM ;

VANMEERSSCHE, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (05) :694-700

[7] NUCLEAR MAGNETIC-RESONANCE STUDY OF THE DEGRADATION OF PENICILLIN-G IN ACIDIC SOLUTION [J].

DEGELAEN, JP ;

LOUKAS, SL ;

FEENEY, J ;

ROBERTS, GCK ;

BURGEN, ASV .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1979, (01) :86-90

[8] SPIN-ECHO H-1-NMR SPECTROSCOPY - A NEW METHOD FOR STUDYING PENICILLIN METABOLISM [J].

EVERETT, JR ;

JENNINGS, KR ;

WOODNUTT, G ;

BUCKINGHAM, MJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (14) :894-895

[9] ELIMINATION OF A GOOD LEAVING GROUP FROM THE 3'-POSITION OF A CEPHALOSPORIN NEED NOT BE CONCERTED WITH BETA-LACTAM RING-OPENING - TEM-2 BETA-LACTAMASE-CATALYZED HYDROLYSIS OF PYRIDINE-2-AZO-4'-(N',N'-DIMETHYLANILINE) CEPHALOSPORIN (PADAC) AND OF CEPHALORIDINE [J].

FARACI, WS ;

PRATT, RF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (05) :1489-1490

[10] DELTA-2-CEPHALOSPORINS AND DELTA-3-CEPHALOSPORINS, PENICILLINATE AND 6-UNSUBSTITUTED PENEMS - INTRINSIC REACTIVITY AND INTERACTION WITH BETA-LACTAMASES AND D-ALANYL-D-ALANINE-CLEAVING SERINE PEPTIDASES [J].

FRERE, JM ;

KELLY, JA ;

KLEIN, D ;

GHUYSEN, JM ;

CLAES, P ;

VANDERHAEGHE, H .

BIOCHEMICAL JOURNAL, 1982, 203 (01) :223-234

← 1 2 3 →