2 SYNTHETIC PHOSPHONATE ANALOGS OF LECITHIN

被引：15

作者：

ROSENTHAL, AF

POUSADA, M

机构：

[1] Department of Laboratories, The Long Island Jewish Hospital, New Hyde Park, 11040, New York

来源：

LIPIDS | 1969年 / 4卷 / 01期

关键词：

D O I：

10.1007/BF02531792

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The diether-phosphonate lecithin analog DL-2-hexadecoxy-3-octadecoxypropyl-phosphonylcholine was prepared in 55% overall yield by reaction of 2-hexadecoxy-3-octadecoxypropylphosphonic acid with choline iodide and p-toluenesulfonyl chloride, and purified chromatographically. The diester-phosphonate lecithin analog 1,2-dipalmitoyl-sn-glycero-3-[2′-trimethyl-ammonium) ethylphosphonate) was prepared from sn-glycerol-1,2-dipalmitate and 2-(trimethylammonium) ethylphosphonyl dichloride, and the reaction mixture purified chromatographically. The lecithin analog was obtained in an anhydrous form. © 1969 American Oil Chemists' Society.

引用

页码：37 / +

页数：1

共 22 条

[1]

BAER E, 1965, J BIOL CHEM, V240, P44

[2]

BAER E, 1964, J BIOL CHEM, V239, P3209

[3] PHOSPHONOLIPIDS .7. SYNTHESIS OF PHOSPHONIC ACID ANALOGUES OF DIETHER L-ALPHA-LECITHINS [J].