GLYCOSYLIMIDATES .46. TOTAL SYNTHESIS OF A HEXAOSYL CERAMIDE GLYCOLIPID ACTING AS A RECEPTOR FOR MACROPHAGE-MIGRATION INHIBITION-FACTOR

被引:33
作者
ZIMMERMANN, P [1 ]
GREILICH, U [1 ]
SCHMIDT, RR [1 ]
机构
[1] UNIV CONSTANCE,FAK CHEM,W-7750 CONSTANCE,GERMANY
关键词
D O I
10.1016/S0040-4039(00)98802-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A synthesis of the glycosphingolipid1 constituting a macrophage receptor for MIF is described. It is based on trichloroacetimidate glycosyl donors and on the azidosphingosine glycosylation method. Regioselective O-glycosylation of a partially O-protected acceptor and direct transformation of the sphingosine azido group into a fatty acyl amido function were successfully applied in the execution of the synthesis. © 1990 Pergamon Press plc.
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页码:1849 / 1852
页数:4
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