DETERMINATION OF HYDRATION EQUILIBRIUM-CONSTANTS AND PKA VALUES OF 4-PIPERIDONES IN BUFFERED WATER SOLUTIONS

被引：17

作者：

VANLUPPEN, JJ ^{[1
]}

LEPOIVRE, JA ^{[1
]}

DOMMISSE, RA ^{[1
]}

ALDERWEIRELDT, FC ^{[1
]}

机构：

[1] UNIV ANTWERP,ORGAN CHEM LAB,B-2020 ANTWERP,BELGIUM

来源：

ORGANIC MAGNETIC RESONANCE | 1979年 / 12卷 / 07期

关键词：

D O I：

10.1002/mrc.1270120704

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

1H and 13C chemical shift parameters are given for 4‐piperidones and their derivatives in buffered aqueous solution. The 13C shift increments of methyl substituents on the nitrogen atom are discussed. The pH‐shift dependence is studied in detail and pKa values are given for ketone forms and hydration products. The hydration equilibria are measured as a function of pH and temperature. Copyright © 1979 Heyden & Son Ltd.

引用

页码：399 / 404

页数：6

共 15 条

[1] CONFORMATIONAL-ANALYSIS .81. GAMMA-PIPERIDONE AND RELATED COMPOUNDS [J].