NOVEL OLIGOSACCHARIDES WITH THE SIALYL-LEA STRUCTURE IN HUMAN-MILK

被引:20
作者
KITAGAWA, H
NAKADA, H
FUKUI, S
FUNAKOSHI, I
KAWASAKI, T
YAMASHINA, I
TATE, S
INAGAKI, F
机构
[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT BIOL CHEM,SAKYO KU,KYOTO 606,JAPAN
[2] KYOTO SANGYO UNIV,FAC ENGN,DEPT BIOTECHNOL,KITA KU,KYOTO 603,JAPAN
[3] TOKYO METROPOLITAN INST MED SCI,DEPT MOLEC PHYSIOL,BUNKYO KU,TOKYO 113,JAPAN
关键词
D O I
10.1021/bi00225a020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have isolated four novel oligosaccharides with the sialyl-Le(a) structure from human milk using a monoclonal antibody, MSW 113. These oligosaccharides were purified by affinity chromatography on a column of the immobilized monoclonal antibody and by high-performance liquid chromatography. The results of structural analyses, i.e., 500-MHz H-1 NMR spectroscopy, fast atom bombardment mass spectrometry, and binding to specific anticarbohydrate antibodies, are consistent with the following structures. [GRAPHICS]
引用
收藏
页码:2869 / 2876
页数:8
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