INVITRO BIOSYNTHESIS OF STEROIDS FROM CHOLESTEROL BY THE OVARIES AND PYLORIC CECA OF THE STARFISH ASTERIAS-RUBENS

被引：47

作者：

SCHOENMAKERS, HJN ^{[1
]}

机构：

[1] UNIV UTRECHT,ZOOL LAB,COMPARAT ENDOCRINOL SECT,NL-3508 TB UTRECHT,NETHERLANDS

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1979年 / 63卷 / 02期

关键词：

D O I：

10.1016/0305-0491(79)90026-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. In vitro biosynthesis of steroids from cholesterol in ovaries and pyloric caeca of Asterias rubens has been investigated. 2. 2. The formation of pregnenolone and progesterone was demonstrated in both tissues by using 1,2-3H-cholesterol as a precursor. 3. 3. Pregnenolone and progesterone are produced in small quantities; the ovaries appear to be more active in the biosynthesis of these steroids than the pyloric caeca. 4. 4. The results indicate the presence of the following biosynthetic enzyme systems in ovaries and pyloric caeca of Asterias rubens: a side-chain-cleaving enzyme complex and a Δ5-Δ4-isomerase-3β-HSD complex. 5. 5. The importance of these enzymes and the function of cholesterol for the biosynthesis of steroids will be discussed. © 1979.

引用

页码：179 / 184

页数：6

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