ASSIGNMENT OF THE HUMAN INTERFERON REGULATORY FACTOR-I (IRF1) GENE TO CHROMOSOME 5Q23-Q31

被引：51

作者：

ITOH, S

HARADA, H

NAKAMURA, Y

WHITE, R

TANIGUCHI, T

机构：

[1] OSAKA UNIV,INST MOLEC & CELLULAR BIOL,SUITA,OSAKA 565,JAPAN

[2] UNIV UTAH,MED CTR,DEPT HUMAN GENET,SALT LAKE CITY,UT 84132

[3] UNIV UTAH,MED CTR,HOWARD HUGHES,SALT LAKE CITY,UT 84132

来源：

GENOMICS | 1991年 / 10卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90208-V

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

It has been shown that a nuclear factor, interferon regulatory factor-1 (IRF1), plays a key role in the regulation of the type I interferon (IFN) system by affecting the transcription of type I IFN and some IFN-inducible genes. In this study, the human IRF1 gene was mapped to chromosome 5 by analysis of mouse-human somatic cell hybrids. Furthermore, by linkage analysis based on RFLP (restriction fragment length polymorphism), the gene was localized to chromosome 5q23-q31, the region that has been termed "critical" for some myeloid disorders. © 1991.

引用

页码：1097 / 1099

页数：3

共 13 条

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