MORPHOLOGICAL AND MORPHOMETRIC ANALYSES OF RAT FEMORAL ARTERIES AFTER CRUSH INJURY

被引：14

作者：

CHEN, LE ^{[1
]}

SEABER, AV ^{[1
]}

GLISSON, RR ^{[1
]}

MIKAT, EM ^{[1
]}

URBANIAK, JR ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT SURG,POB 3093,DURHAM,NC 27710

来源：

MICROSURGERY | 1991年 / 12卷 / 06期

关键词：

D O I：

10.1002/micr.1920120607

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Replantation after crush amputation has a relatively low success rate. An arterial crush injury was produced in rats under a range of pressure (8.5 to 2,551 g/mm2) and durations (10 to 60 minutes). The degrees of vessel injury and thrombus formation were evaluated as functions of both crush force and duration, and the healing process was followed for 8 weeks. Crushing resulted in morphologic damage to the arterial wall but did not impair patency. Damage was directly proportional to crush pressure and duration. Intimal denudation caused flat platelet adhesion but no thrombus formation or thrombosis. Reendothelialization was completed by 2 weeks. Intimal hyperplasia appeared at 1 week and consisted of endothelia in the most luminal layers and smooth muscle in the deeper layers. The internal elastic lamina was intact in all specimens and was thought to minimize platelet aggregation on the arterial wall after denudation of the intima.

引用

页码：402 / 411

页数：10

共 44 条

[1] Chen ZW, Yang DY, Chang DS, Microsurgery, Shanghai Scientific and Technical Publishers, pp. 105-140, (1982)
[2] Harker LA, Disorders of hemostasis thrombosis, Hematology, pp. 1559-1569, (1990)
[3] Verstraete M, Dejana E, Fuster V, Lapetina E, Moncada S, Mustard JF, Tans G, Vargaftig BB, An overview of antiplatelet and antithrombotic drugs, Haemostasis, 15, pp. 89-99, (1985)
[4] Mustard JF, Kinlough-Rathbone RL, Packham MA, The vessel wall in thrombosis, Hemostasis and Thrombosis. Basic Principles and Clinical Practice, pp. 1073-1088, (1987)
[5] Acland RD, Trachtenberg L, The histopathology of small arteries following experimental microvascular anastomosis, Plast Reconstr Surg, 59, pp. 868-875, (1977)
[6] Harashina T, Fujino T, Watanabe S, The intimal healing of microvascular anastomoses, Plast Reconstr Surg, 58, pp. 608-613, (1976)
[7] Isogai N, Kamiishi H, Chichibu S, Re‐endothelialization stages at the microvascular anastomosis, Microsurgery, 9, pp. 87-92, (1988)
[8] Lidman D, Daniel RK, The normal healing process of microvascular anastomoses, Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, 15, pp. 103-110, (1981)
[9] Mitchell GM, Ultrastructural microvascular repair, Reconstructive Microsurgery, pp. 89-113, (1987)
[10] Rosenbaum TJ, Sundt TM, Thrombus formation and endothelial alterations in microarterial anastomoses, J Neurosurg, 47, pp. 430-441, (1977)

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