MUTAGENICITY OF PYRROLIZIDINE ALKALOIDS IN THE SALMONELLA-MAMMALIAN-MICROSOME TEST

被引：89

作者：

YAMANAKA, H

NAGAO, M

SUGIMURA, T

FURUYA, T

SHIRAI, A

MATSUSHIMA, T

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

[2] UNIV TOKYO,INST MED SCI,MINATO KU,DEPT MOLEC ONCOL,TOKYO 108,JAPAN

来源：

MUTATION RESEARCH | 1979年 / 68卷 / 03期

关键词：

D O I：

10.1016/0165-1218(79)90152-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mutagenicities of 7 pyrrolizidine alkaloids to Salmonella typhimurium TA100 were demonstrated by a modified Ames's method. The pyrrolizidine alkaloids found to be mutagenic were clivorine, fukinotoxin, heliotrine, lasiocarpine, ligularidine, LX201 and senkirkine. Pre-incubation of these alkaloids with S9 mix and bacteria in a liquid medium was essential for demonstration of their mutagenicities. © 1979.

引用

页码：211 / 216

页数：6

共 24 条

[1] INTERLOCUS SPECIFICITY FOR CHEMICAL MUTAGENS IN ASPERGILLUS NIDULANS [J].