EVIDENCE FOR ADENOSINE-A(2B) RECEPTORS IN THE RAT PINEAL-GLAND

被引：17

作者：

GHARIB, A

DELTON, I

LAGARDE, M

SARDA, N

机构：

[1] INSERM U352, INSA, Laboratoire de Chimie Biologique

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 225卷 / 04期

关键词：

PINEAL; ADENOSINE RECEPTORS; AMP;

D O I：

10.1016/0922-4106(92)90113-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We describe the effects of 5'-N-ethylcarboxamidoadenosine (NECA), a mixed A2a/A2b adenosine receptor agonist and 2-[p-(carboxyethyl)-phenylethylamino]-5'-N-ethylcarboxamidoadenosine (CGS 21680), a selective A2a agonist, on cyclic AMP and N-acetylserotonin synthesis in rat pineal gland. NECA, 1 and 10-mu-M, increased cyclic AMP by 5- and 25-fold and N-acetylserotonin by 40- and 60-fold respectively, whereas CGS 21680 at the same concentrations was ineffective. These results argue for the presence of adenosine A2b receptors in rat pinealocytes.

引用

页码：359 / 360

页数：2

共 6 条

[1]

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[2]

BRUNS RF, 1986, MOL PHARMACOL, V29, P331

[3]

GHARIB A, 1991, ADV PINEAL, V5, P47

[4]

JARVIS MF, 1989, J PHARMACOL EXP THER, V251, P888

[5]

LUPICA CR, 1990, J PHARMACOL EXP THER, V252, P1134

[6] IDENTIFICATION OF ADENOSINE RECEPTOR IN RAT PINEAL-GLAND - EVIDENCE FOR A-2 SELECTIVITY [J].

SARDA, N ;

GHARIB, A ;

REYNAUD, D ;

OU, L ;

PACHECO, H .

JOURNAL OF NEUROCHEMISTRY, 1989, 53 (03) :733-737

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