ANTIINFLAMMATORY ACTIVITY OF OLEANOLIC ACID IN RATS AND MICE

被引：182

作者：

SINGH, GB ^{[1
]}

SINGH, S ^{[1
]}

BANI, S ^{[1
]}

GUPTA, BD ^{[1
]}

BANERJEE, SK ^{[1
]}

机构：

[1] REG RES LAB, DIV NAT PROD CHEM, JAMMU 180001, INDIA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 05期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb03646.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oleanolic acid displayed anti-inflammatory activity in carrageenan and dextran-induced oedema in rats. It elicited marked anti-arthritic action in adjuvant-induced polyarthritis in rats and mice and in formaldehyde-induced arthritis in rats. Oleanolic acid checked the inflammation-induced increased serum transaminase levels. It reduced exudate volume and inhibited leucocyte infiltration in carrageenan-induced pleurisy in rats. It is devoid of any analgesic, antipyretic or ulcerogenic action. Oleanolic acid did not affect the parturition time in pregnant rats or castor oil-induced diarrhoea in rats. Oral LD50 was found to be greater than 2 g kg-1 in mice and rats.

引用

页码：456 / 458

页数：3

共 27 条

[1] ASPIRIN AND INDOMETHACIN PROLONG PARTURITION IN RATS - EVIDENCE THAT PROSTAGLANDINS CONTRIBUTE TO EXPULSION OF FETUS [J].