RECENT ADVANCES IN MINISATELLITE BIOLOGY

被引：14

作者：

ARMOUR, JAL

JEFFREYS, AJ

机构：

来源：

FEBS LETTERS | 1992年 / 307卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0014-5793(92)80912-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Highly polymorphic tandemly repeated 'minisatellite' loci are very abundant in the human genome, and of considerable utility in human genetic analysis. This review describes the use of an ordered-array Charomid library in the systematic and efficient cloning of these regions, and in the analysis of the relative overlap between the different probes used to screen for hypervariable loci. Recent work on the process of mutation leading to the generation of new-length alleles is also discussed, including the observation that at least some mutations may be due to unequal exchanges.

引用

收藏

页码：113 / 115

页数：3

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